Blocking cell cycle progression through CDK4/6 protects against chronic kidney disease

Blocking cell cycle progression through CDK4/6 protects against chronic kidney disease

Acute and chronic kidney injuries induce increased cell cycle progression in renal tubules. While increased cell cycle progression promotes repair after acute injury, the role of ongoing tubular cell cycle progression in chronic kidney disease is unknown. Two weeks after initiation of chronic kidney...

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Bibliographic Details
Main Authors: Yosuke Osaki, Marika Manolopoulou, Alla V. Ivanova, Nicholas Vartanian, Melanie Phillips Mignemi, Justin Kern, Jianchun Chen, Haichun Yang, Agnes B. Fogo, Mingzhi Zhang, Cassianne Robinson-Cohen, Leslie S. Gewin
Format: Article
Language:English
Published: American Society for Clinical investigation 2022-06-01
Series:JCI Insight
Subjects:
Nephrology
Online Access:https://doi.org/10.1172/jci.insight.158754

Internet

https://doi.org/10.1172/jci.insight.158754

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