Anti-α4 antibody treatment blocks virus traffic to the brain and gut early, and stabilizes CNS injury late in infection.

Anti-α4 antibody treatment blocks virus traffic to the brain and gut early, and stabilizes CNS injury late in infection.

Four SIV-infected monkeys with high plasma virus and CNS injury were treated with an anti-α4 blocking antibody (natalizumab) once a week for three weeks beginning on 28 days post-infection (late). Infection in the brain and gut were quantified, and neuronal injury in the CNS was assessed by MR spect...

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Bibliographic Details
Main Authors: Jennifer H Campbell, Eva-Maria Ratai, Patrick Autissier, David J Nolan, Samantha Tse, Andrew D Miller, R Gilberto González, Marco Salemi, Tricia H Burdo, Kenneth C Williams
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-12-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC4263764?pdf=render

Internet

http://europepmc.org/articles/PMC4263764?pdf=render

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