Quality by Design for the Development and Analysis of Enhanced In-Situ Forming Vesicles for the Improvement of the Bioavailability of Fexofenadine HCl In Vitro and In Vivo

Quality by Design for the Development and Analysis of Enhanced In-Situ Forming Vesicles for the Improvement of the Bioavailability of Fexofenadine HCl In Vitro and In Vivo

Drug absorption from the gastrointestinal tract (GIT) is one of the major problems affecting the bioavailability of orally absorbed drugs. This work aims to enhance Fexofenadine HCl oral bioavailability in vivo, the drug used for allergic rhinitis. In this study, novel spray-dried lactose-based enha...

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Bibliographic Details
Main Authors: Ali M. Nasr, Mona K. Qushawy, Mahmoud M. Elkhoudary, Aya Y. Gawish, Sameh S. Elhady, Shady A. Swidan
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Pharmaceutics
Subjects:
enhanced in-situ formed vesicles
absorption enhancers
fexofenadine
allergic rhinitis
experimental design
central composite design
Online Access:https://www.mdpi.com/1999-4923/12/5/409

Internet

https://www.mdpi.com/1999-4923/12/5/409

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