Serum Cytokine Profile, Beta-Hexosaminidase A Enzymatic Activity and GM<sub>2</sub> Ganglioside Levels in the Plasma of a Tay-Sachs Disease Patient after Cord Blood Cell Transplantation and Curcumin Administration: A Case Report

Serum Cytokine Profile, Beta-Hexosaminidase A Enzymatic Activity and GM<sub>2</sub> Ganglioside Levels in the Plasma of a Tay-Sachs Disease Patient after Cord Blood Cell Transplantation and Curcumin Administration: A Case Report

Tay-Sachs disease (TSD) is a progressive neurodegenerative disorder that occurs due to a deficiency of a β hexosaminidase A (HexA) enzyme, resulting in the accumulation of GM<sub>2</sub> gangliosides. In this work, we analyzed the effect of umbilical cord blood cell transplantation (UCBC...

Full description

Bibliographic Details
Main Authors: Alisa A. Shaimardanova, Daria S. Chulpanova, Valeriya V. Solovyeva, Ekaterina E. Garanina, Ilnur I. Salafutdinov, Alexander Vladimirovich Laikov, Vadim V. Kursenko, Lisa Chakrabarti, Ekaterina Yu. Zakharova, Tatiana M. Bukina, Galina V. Baydakova, Albert Anatolyevich Rizvanov
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Life
Subjects:
lysosomal storage diseases
Tay-Sachs disease
GM<sub>2</sub> gangliosidosis
β hexosaminidase A
cytokine profile
curcumin
Online Access:https://www.mdpi.com/2075-1729/11/10/1007

Internet

https://www.mdpi.com/2075-1729/11/10/1007

Similar Items