Tempo-spatial regulation of the Wnt pathway by FAM13A modulates the stemness of alveolar epithelial progenitors

Tempo-spatial regulation of the Wnt pathway by FAM13A modulates the stemness of alveolar epithelial progenitors

Background: Family with Sequence Similarity 13, Member A (FAM13A) gene has been consistently associated with COPD by Genome-wide association studies (GWAS). Our previous study demonstrated that FAM13A was mainly expressed in the lung epithelial progenitors including Club cells and alveolar type II e...

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Bibliographic Details
Main Authors: Xin Lin, Yujun Li, Lu Gong, Jeong H. Yun, Shuang Xu, Yohannes Tesfaigzi, Dandi Qiao, Xiaobo Zhou
Format: Article
Language:English
Published: Elsevier 2021-07-01
Series:EBioMedicine
Subjects:
FAM13A
β-catenin/Wnt pathway
Repair/regeneration
Epithelial organoids
Cigarette smoke
COPD/emphysema
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396421002565

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http://www.sciencedirect.com/science/article/pii/S2352396421002565

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