Anti-obesity carbonic anhydrase inhibitors: challenges and opportunities

Anti-obesity carbonic anhydrase inhibitors: challenges and opportunities

The mitochondrial isoforms VA/VB of metalloenzyme carbonic anhydrase (CA, EC 4.2.1.1) are involved in metabolic processes, such as de novo lipogenesis and fatty acid biosynthesis. We review the drug design landscape for obtaining CA VA/VB-selective/effective inhibitors, starting from the clinical ob...

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Bibliographic Details
Main Author: Claudiu T. Supuran
Format: Article
Language:English
Published: Taylor & Francis Group 2022-12-01
Series:Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:
Carbonic anhydrase
mitochondria
de novo lipogenesis
fatty acid biosynthesis
obesity
topiramate
Online Access:https://www.tandfonline.com/doi/10.1080/14756366.2022.2121393

Internet

https://www.tandfonline.com/doi/10.1080/14756366.2022.2121393

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