miR-378 Activates the Pyruvate-PEP Futile Cycle and Enhances Lipolysis to Ameliorate Obesity in Mice

miR-378 Activates the Pyruvate-PEP Futile Cycle and Enhances Lipolysis to Ameliorate Obesity in Mice

Obesity has been linked to many health problems, such as diabetes. However, there is no drug that effectively treats obesity. Here, we reveal that miR-378 transgenic mice display reduced fat mass, enhanced lipolysis, and increased energy expenditure. Notably, administering AgomiR-378 prevents and am...

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Bibliographic Details
Main Authors: Yong Zhang, Changyin Li, Hu Li, Yipeng Song, Yixia Zhao, Lili Zhai, Haixia Wang, Ran Zhong, Huiru Tang, Dahai Zhu
Format: Article
Language:English
Published: Elsevier 2016-03-01
Series:EBioMedicine
Subjects:
miR-378
Futile cycle
Lipolysis
Energy homeostasis
Obesity
SCD1
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396416300317

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http://www.sciencedirect.com/science/article/pii/S2352396416300317

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