Behavior of Regular Insulin in a Parenteral Nutrition Admixture: Validation of an LC/MS-MS Assay and the In Vitro Evaluation of Insulin Glycation

Behavior of Regular Insulin in a Parenteral Nutrition Admixture: Validation of an LC/MS-MS Assay and the In Vitro Evaluation of Insulin Glycation

Parenteral-nutrition (PN)-induced hyperglycemia increases morbidity and mortality and must be treated with insulin. Unfortunately, the addition of insulin to a ternary PN admixture leads to a rapid decrease in insulin content. Our study’s objective was to determine the mechanistic basis of insulin’s...

Full description

Bibliographic Details
Main Authors: Heloise Henry, Jean-François Goossens, Mostafa Kouach, Damien Lannoy, David Seguy, Thierry Dine, Pascal Odou, Catherine Foulon
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Pharmaceutics
Subjects:
regular insulin
drug stability study
parenteral nutrition admixture
glycation
LC-MS/MS
Online Access:https://www.mdpi.com/1999-4923/14/5/1081

Internet

https://www.mdpi.com/1999-4923/14/5/1081

Similar Items