Cellular senescence or stemness: hypoxia flips the coin

Abstract Cellular senescence is a complex physiological state whose main feature is proliferative arrest. Cellular senescence can be considered the reverse of cell immortalization and continuous tumor growth. However, cellular senescence has many physiological functions beyond being a putative tumor...

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Bibliographic Details
Main Authors: Daniel Otero-Albiol, Amancio Carnero
Format: Article
Language:English
Published: BMC 2021-07-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Online Access:https://doi.org/10.1186/s13046-021-02035-0