Cellular senescence or stemness: hypoxia flips the coin
Abstract Cellular senescence is a complex physiological state whose main feature is proliferative arrest. Cellular senescence can be considered the reverse of cell immortalization and continuous tumor growth. However, cellular senescence has many physiological functions beyond being a putative tumor...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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BMC
2021-07-01
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| Series: | Journal of Experimental & Clinical Cancer Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13046-021-02035-0 |
| _version_ | 1818649124941070336 |
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| author | Daniel Otero-Albiol Amancio Carnero |
| author_facet | Daniel Otero-Albiol Amancio Carnero |
| author_sort | Daniel Otero-Albiol |
| collection | DOAJ |
| description | Abstract Cellular senescence is a complex physiological state whose main feature is proliferative arrest. Cellular senescence can be considered the reverse of cell immortalization and continuous tumor growth. However, cellular senescence has many physiological functions beyond being a putative tumor suppressive trait. It remains unknown whether low levels of oxygen or hypoxia, which is a feature of every tissue in the organism, modulate cellular senescence, altering its capacity to suppress the limitation of proliferation. It has been observed that the lifespan of mammalian primary cells is increased under low oxygen conditions. Additionally, hypoxia promotes self-renewal and pluripotency maintenance in adult and embryonic stem cells (ESCs), induced pluripotent stem cells (iPSCs) and cancer stem cells (CSCs). In this study, we discuss the role of hypoxia facilitating senescence bypass during malignant transformation and acquisition of stemness properties, which all contribute to tumor development and cancer disease aggressiveness. |
| first_indexed | 2024-12-17T01:29:20Z |
| format | Article |
| id | doaj.art-082c485ca22e4ed7b2300298528e8aac |
| institution | Directory Open Access Journal |
| issn | 1756-9966 |
| language | English |
| last_indexed | 2024-12-17T01:29:20Z |
| publishDate | 2021-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Experimental & Clinical Cancer Research |
| spelling | doaj.art-082c485ca22e4ed7b2300298528e8aac2022-12-21T22:08:37ZengBMCJournal of Experimental & Clinical Cancer Research1756-99662021-07-0140112010.1186/s13046-021-02035-0Cellular senescence or stemness: hypoxia flips the coinDaniel Otero-Albiol0Amancio Carnero1Instituto de Biomedicina de Sevilla, IBIS, Hospital Universitario Virgen del Rocío, Universidad de Sevilla, Consejo Superior de Investigaciones CientíficasInstituto de Biomedicina de Sevilla, IBIS, Hospital Universitario Virgen del Rocío, Universidad de Sevilla, Consejo Superior de Investigaciones CientíficasAbstract Cellular senescence is a complex physiological state whose main feature is proliferative arrest. Cellular senescence can be considered the reverse of cell immortalization and continuous tumor growth. However, cellular senescence has many physiological functions beyond being a putative tumor suppressive trait. It remains unknown whether low levels of oxygen or hypoxia, which is a feature of every tissue in the organism, modulate cellular senescence, altering its capacity to suppress the limitation of proliferation. It has been observed that the lifespan of mammalian primary cells is increased under low oxygen conditions. Additionally, hypoxia promotes self-renewal and pluripotency maintenance in adult and embryonic stem cells (ESCs), induced pluripotent stem cells (iPSCs) and cancer stem cells (CSCs). In this study, we discuss the role of hypoxia facilitating senescence bypass during malignant transformation and acquisition of stemness properties, which all contribute to tumor development and cancer disease aggressiveness.https://doi.org/10.1186/s13046-021-02035-0hypoxiaoxygencellular senescenceimmortalizationcancerstemness |
| spellingShingle | Daniel Otero-Albiol Amancio Carnero Cellular senescence or stemness: hypoxia flips the coin Journal of Experimental & Clinical Cancer Research hypoxia oxygen cellular senescence immortalization cancer stemness |
| title | Cellular senescence or stemness: hypoxia flips the coin |
| title_full | Cellular senescence or stemness: hypoxia flips the coin |
| title_fullStr | Cellular senescence or stemness: hypoxia flips the coin |
| title_full_unstemmed | Cellular senescence or stemness: hypoxia flips the coin |
| title_short | Cellular senescence or stemness: hypoxia flips the coin |
| title_sort | cellular senescence or stemness hypoxia flips the coin |
| topic | hypoxia oxygen cellular senescence immortalization cancer stemness |
| url | https://doi.org/10.1186/s13046-021-02035-0 |
| work_keys_str_mv | AT danieloteroalbiol cellularsenescenceorstemnesshypoxiaflipsthecoin AT amanciocarnero cellularsenescenceorstemnesshypoxiaflipsthecoin |