Enhancement of LPS-Induced Microglial Inflammation Response via TLR4 Under High Glucose Conditions

Enhancement of LPS-Induced Microglial Inflammation Response via TLR4 Under High Glucose Conditions

Background: Microglia activation mediated by toll-like receptor 4 (TLR4) plays an important role in neuroinflammation and postoperative cognitive dysfunction (POCD). Diabetes mellitus (DM) has been recently suggested as an independent risk factor for POCD. In this study, we investigate the potential...

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Bibliographic Details
Main Authors: Xiang Zhang, Hongquan Dong, Susu Zhang, Shunmei Lu, Jie Sun, Yanning Qian
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2015-03-01
Series:Cellular Physiology and Biochemistry
Subjects:
High glucose
Microglia
JAK2/STAT3
TLR4
Online Access:http://www.karger.com/Article/FullText/373972

Internet

http://www.karger.com/Article/FullText/373972

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