Enhanced sialylation and in vivo efficacy of recombinant human α-galactosidase through in vitro glycosylation

Enhanced sialylation and in vivo efficacy of recombinant human α-galactosidase through in vitro glycosylation

Human α-galactosidase A (GLA) has been used in enzymereplacement therapy for patients with Fabry disease. Weexpressed recombinant GLA from Chinese hamster ovary cellswith very high productivity. When compared to an approvedGLA (agalsidase beta), its size and charge were found to besmaller and more n...

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Bibliographic Details
Main Authors: Youngsoo Sohn, Jung Mi Lee, Heung-Rok Park, Sung-Chul Jung, Tai Hyun Park, Doo-Byoung Oh
Format: Article
Language:English
Published: Korean Society for Biochemistry and Molecular Biology 2013-03-01
Series:BMB Reports
Subjects:
Alpha-galactosidase A
Enzyme replacement therapy
Fabry disease
In vitro glycosylation
Sialic acid
Online Access:http://bmbreports.org/jbmb/pdf.php?data=MTMwOTI3MTBAcGRmX3JhaW50cmFjZV9sZWV5c0AlNUI0Ni0zJTVEMTMwMzI3MjEzMl8lMjgxNTctMTYyJTI5Qk1CXzEyLTE5Mi5wZGY=

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http://bmbreports.org/jbmb/pdf.php?data=MTMwOTI3MTBAcGRmX3JhaW50cmFjZV9sZWV5c0AlNUI0Ni0zJTVEMTMwMzI3MjEzMl8lMjgxNTctMTYyJTI5Qk1CXzEyLTE5Mi5wZGY=

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