McsB forms a gated kinase chamber to mark aberrant bacterial proteins for degradation

McsB forms a gated kinase chamber to mark aberrant bacterial proteins for degradation

In Gram-positive bacteria, the McsB protein arginine kinase is central to protein quality control, labeling aberrant molecules for degradation by the ClpCP protease. Despite its importance for stress response and pathogenicity, it is still elusive how the bacterial degradation labeling is regulated....

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Bibliographic Details
Main Authors: Bence Hajdusits, Marcin J Suskiewicz, Nikolas Hundt, Anton Meinhart, Robert Kurzbauer, Julia Leodolter, Philipp Kukura, Tim Clausen
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-07-01
Series:eLife
Subjects:
protein quality control
targeted protein degradation
protein phosphorylation
self-compartmentalization
mass photometry
Online Access:https://elifesciences.org/articles/63505

Internet

https://elifesciences.org/articles/63505

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