A high-throughput microfluidic device based on controlled incremental filtration to enable centrifugation-free, low extracorporeal volume leukapheresis

Abstract Leukapheresis, the extracorporeal separation of white blood cells (WBCs) from red blood cells (RBCs) and platelets (PLTs), is a life-saving procedure used for treating patients with cancer and other conditions, and as the initial step in the manufacturing of cellular and gene-based therapie...

Full description

Bibliographic Details
Main Authors: Dalia L. Lezzar, Fong W. Lam, Ravin Huerta, Anton Mukhamedshin, Madeleine Lu, Sergey S. Shevkoplyas
Format: Article
Language:English
Published: Nature Portfolio 2022-08-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-16748-5