Defactinib inhibits PYK2 phosphorylation of IRF5 and reduces intestinal inflammation

Defactinib inhibits PYK2 phosphorylation of IRF5 and reduces intestinal inflammation

The transcription factor, IRF5, has been implicated in the regulation of inflammation, but how IRF5 protein is activated is still unclear. Here the authors use inhibitor library screening, biochemical analyses and in vivo/ex vivo data to show that a protein tyrosine kinase, Pyk2, may be key for the...

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Dettagli Bibliografici
Autori principali: Grigory Ryzhakov, Hannah Almuttaqi, Alastair L. Corbin, Dorothée L. Berthold, Tariq Khoyratty, Hayley L. Eames, Samuel Bullers, Claire Pearson, Zhichao Ai, Kristina Zec, Sarah Bonham, Roman Fischer, Luke Jostins-Dean, Simon P. L. Travis, Benedikt M. Kessler, Irina A. Udalova
Natura: Articolo
Lingua:English
Pubblicazione: Nature Portfolio 2021-11-01
Serie:Nature Communications
Accesso online:https://doi.org/10.1038/s41467-021-27038-5

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https://doi.org/10.1038/s41467-021-27038-5

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