Protein citrullination marks myelin protein aggregation and disease progression in mouse ALS models

Protein citrullination marks myelin protein aggregation and disease progression in mouse ALS models

Abstract Increased protein citrullination (PC) and dysregulated protein arginine deiminase (PAD) activity have been observed in several neurodegenerative diseases. PC is a posttranslational modification catalyzed by the PADs. PC converts peptidyl-arginine to peptidyl-citrulline, thereby reducing the...

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Bibliographic Details
Main Authors: Issa O. Yusuf, Tao Qiao, Sepideh Parsi, Ronak Tilvawala, Paul R. Thompson, Zuoshang Xu
Format: Article
Language:English
Published: BMC 2022-09-01
Series:Acta Neuropathologica Communications
Subjects:
Neurodegeneration
Deimination
Neurodegenerative disease
Myelin degeneration
Astrogliosis
Protein aggregation
Online Access:https://doi.org/10.1186/s40478-022-01433-5

Internet

https://doi.org/10.1186/s40478-022-01433-5

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