Design and synthesis of new thiazolidinone/uracil derivatives as antiproliferative agents targeting EGFR and/or BRAFV600E

Design and synthesis of new thiazolidinone/uracil derivatives as antiproliferative agents targeting EGFR and/or BRAFV600E

Thiourea derivatives of uracil were efficiently synthesized via the reaction of 5-aminouracil with isothiocyanates. Then, we prepared uracil-containing thiazoles via condensation of thioureas with diethyl/dimethyl acetylenedicarboxylates. The structures of the products were confirmed by a combinatio...

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Bibliographic Details
Main Authors: Mohammed B. Alshammari, Ashraf A. Aly, Bahaa G. M. Youssif, Stefan Bräse, Akil Ahmad, Alan B. Brown, Mahmoud A. A. Ibrahim, Asmaa H. Mohamed
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-12-01
Series:Frontiers in Chemistry
Subjects:
5-AU
thiourea
thiazolidinone
EGFR
B-RAF
viability
Online Access:https://www.frontiersin.org/articles/10.3389/fchem.2022.1076383/full

Internet

https://www.frontiersin.org/articles/10.3389/fchem.2022.1076383/full

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