lncRNA PVT1/MicroRNA-17-5p/PTEN Axis Regulates Secretion of E2 and P4, Proliferation, and Apoptosis of Ovarian Granulosa Cells in PCOS

lncRNA PVT1/MicroRNA-17-5p/PTEN Axis Regulates Secretion of E2 and P4, Proliferation, and Apoptosis of Ovarian Granulosa Cells in PCOS

Recently, the roles of microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) were identified in polycystic ovary syndrome (PCOS). In the present study, we investigated the role of the lncRNA PVT1/miR-17-5p/PTEN axis in PCOS ovarian granulosa cells. Expression of PVT1, miR-17-5p and PTEN in PCOS ovar...

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Bibliographic Details
Main Authors: Gelin Liu, Shengxian Liu, Guanlin Xing, Fang Wang
Format: Article
Language:English
Published: Elsevier 2020-06-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
long non-coding RNA PVT1
microRNA-17-5p
PTEN
polycystic ovary syndrome
ovarian granulosa cells
apoptosis
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253120300792

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http://www.sciencedirect.com/science/article/pii/S2162253120300792

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