Hepatic Polarized Differentiation Promoted the Maturity and Liver Function of Human Embryonic Stem Cell-Derived Hepatocytes via Activating Hippo and AMPK Signaling Pathways

Hepatic Polarized Differentiation Promoted the Maturity and Liver Function of Human Embryonic Stem Cell-Derived Hepatocytes via Activating Hippo and AMPK Signaling Pathways

Hepatocytes exhibit a multi-polarized state under the in vivo physiological environment, however, human embryonic stem cell-derived hepatocytes (hEHs) rarely exhibit polarity features in a two-dimensional (2D) condition. Thus, we hypothesized whether the polarized differentiation might enhance the m...

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Bibliographic Details
Main Authors: Jue Wang, Ping Situ, Sen Chen, Haibin Wu, Xueyan Zhang, Shoupei Liu, Yiyu Wang, Jinghe Xie, Honglin Chen, Yuyou Duan
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Cells
Subjects:
human embryonic stem cells-derived hepatocytes
hepatic polarized differentiation
hepatocyte polarity
apical membrane
Online Access:https://www.mdpi.com/2073-4409/11/24/4117

Internet

https://www.mdpi.com/2073-4409/11/24/4117

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