Depletion of METTL3 alters cellular and extracellular levels of miRNAs containing m6A consensus sequences

Depletion of METTL3 alters cellular and extracellular levels of miRNAs containing m6A consensus sequences

Extracellular vesicles (EVs) are capable of transferring cargo from donor to recipient cells, but precisely how cargo content is regulated for export is mostly unknown. For miRNA cargo, we previously showed that when compared to isogenic colorectal cancer (CRC) cells expressing wild-type KRAS, a dis...

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Bibliographic Details
Main Authors: Jessica J. Abner, Jeffrey L. Franklin, Margaret A. Clement, Scott A. Hinger, Ryan M. Allen, Xiao Liu, Stefanie Kellner, Junzhou Wu, John Karijolich, Qi Liu, Kasey C. Vickers, Peter Dedon, Alissa M. Weaver, Robert J. Coffey, James G. Patton
Format: Article
Language:English
Published: Elsevier 2021-12-01
Series:Heliyon
Subjects:
miRNA
Base modification
Extracellular vesicle
m6A
RNA
Tumor microenvironment
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844021026220

Internet

http://www.sciencedirect.com/science/article/pii/S2405844021026220

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