Osteopontin depletion in macrophages perturbs proteostasis via regulating UCHL1-UPS axis and mitochondria-mediated apoptosis

Osteopontin depletion in macrophages perturbs proteostasis via regulating UCHL1-UPS axis and mitochondria-mediated apoptosis

IntroductionOsteopontin (OPN; also known as SPP1), an immunomodulatory cytokine highly expressed in bone marrow-derived macrophages (BMMΦ), is known to regulate diverse cellular and molecular immune responses. We previously revealed that glatiramer acetate (GA) stimulation of BMMΦ upregulates OPN ex...

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Bibliographic Details
Main Authors: Altan Rentsendorj, Koen Raedschelders, Dieu-Trang Fuchs, Julia Sheyn, Vineet Vaibhav, Rebecca A. Porritt, Haoshen Shi, Jargalsaikhan Dagvadorj, Juliana de Freitas Germano, Yosef Koronyo, Moshe Arditi, Keith L. Black, Bhakta Prasad Gaire, Jennifer E. Van Eyk, Maya Koronyo-Hamaoui
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Immunology
Subjects:
secreted phosphoprotein 1
early T-lymphocyte activation (ETA-1)
bone/sialoprotein I (BSP-1 or BNSP)
monocytes
innate immunity
mitochondrial dysfunction
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1155935/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1155935/full

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