Usp7-dependent histone H3 deubiquitylation regulates maintenance of DNA methylation

Usp7-dependent histone H3 deubiquitylation regulates maintenance of DNA methylation

Abstract Uhrf1-dependent histone H3 ubiquitylation plays a crucial role in the maintenance of DNA methylation via the recruitment of the DNA methyltransferase Dnmt1 to DNA methylation sites. However, the involvement of deubiquitylating enzymes (DUBs) targeting ubiquitylated histone H3 in the mainten...

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Bibliographic Details
Main Authors: Luna Yamaguchi, Atsuya Nishiyama, Toshinori Misaki, Yoshikazu Johmura, Jun Ueda, Kyohei Arita, Koji Nagao, Chikashi Obuse, Makoto Nakanishi
Format: Article
Language:English
Published: Nature Portfolio 2017-03-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-00136-5

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https://doi.org/10.1038/s41598-017-00136-5

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