Relebactam restores susceptibility of resistant Pseudomonas aeruginosa and Enterobacterales and enhances imipenem activity against chromosomal AmpC-producing species: analysis of global SMART 2018–2020

Relebactam restores susceptibility of resistant Pseudomonas aeruginosa and Enterobacterales and enhances imipenem activity against chromosomal AmpC-producing species: analysis of global SMART 2018–2020

Abstract Background Carbapenem-resistant bacteria are an increasing problem in clinical practice; thus, it is important to identify β-lactamase inhibitors (e.g., relebactam) that can restore carbapenem susceptibility. We report analyses of relebactam enhancement of imipenem activity against both imi...

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Bibliographic Details
Main Authors: David W. Hilbert, C. Andrew DeRyke, Mary Motyl, Meredith Hackel, Katherine Young
Format: Article
Language:English
Published: BMC 2023-06-01
Series:BMC Microbiology
Subjects:
Minimum inhibitory concentration
Gram-negative bacteria
Antibacterial agents
Bacterial infections
Antibacterial susceptibility
Imipenem
Online Access:https://doi.org/10.1186/s12866-023-02864-3

Internet

https://doi.org/10.1186/s12866-023-02864-3

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