Nickel nanoparticle-induced cell transformation: involvement of DNA damage and DNA repair defect through HIF-1α/miR-210/Rad52 pathway

Nickel nanoparticle-induced cell transformation: involvement of DNA damage and DNA repair defect through HIF-1α/miR-210/Rad52 pathway

Abstract Background Nickel nanoparticles (Nano-Ni) are increasingly used in industry and biomedicine with the development of nanotechnology. However, the genotoxic and carcinogenic effects of Nano-Ni and the underlying mechanisms are still unclear. Methods At first, dose–response (0, 10, 20, and 30 ...

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Bibliographic Details
Main Authors: Yiqun Mo, Yue Zhang, Yuanbao Zhang, Jiali Yuan, Luke Mo, Qunwei Zhang
Format: Article
Language:English
Published: BMC 2021-11-01
Series:Journal of Nanobiotechnology
Subjects:
Nickel nanoparticles (Nano-Ni)
DNA damage
HIF-1α
miR-210
Rad52
Cell transformation
Online Access:https://doi.org/10.1186/s12951-021-01117-7

Internet

https://doi.org/10.1186/s12951-021-01117-7

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