Design of a stabilized non-glycosylated Pfs48/45 antigen enables a potent malaria transmission-blocking nanoparticle vaccine

Abstract A malaria vaccine that blocks parasite transmission from human to mosquito would be a powerful method of disrupting the parasite lifecycle and reducing the incidence of disease in humans. Pfs48/45 is a promising antigen in development as a transmission blocking vaccine (TBV) against the dea...

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Bibliographic Details
Main Authors: Thayne H. Dickey, Richi Gupta, Holly McAleese, Tarik Ouahes, Sachy Orr-Gonzalez, Rui Ma, Olga Muratova, Nichole D. Salinas, Jen C. C. Hume, Lynn E. Lambert, Patrick E. Duffy, Niraj H. Tolia
Format: Article
Language:English
Published: Nature Portfolio 2023-02-01
Series:npj Vaccines
Online Access:https://doi.org/10.1038/s41541-023-00619-9