Inflammation‐induced left ventricular fibrosis is partially mediated by tumor necrosis factor‐α

Inflammation‐induced left ventricular fibrosis is partially mediated by tumor necrosis factor‐α

Abstract Objective To determine the mechanisms of inflammation‐induced left ventricular (LV) remodeling and effects of blocking circulating tumor necrosis factor alpha (TNF‐α) in a model of systemic inflammation. Methods Seventy Sprague‐Dawley rats were divided into three groups: the control group,...

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Bibliographic Details
Main Authors: Ashmeetha Manilall, Lebogang Mokotedi, Sulè Gunter, Regina Le Roux, Serena Fourie, Colleen A. Flanagan, Aletta M.E. Millen
Format: Article
Language:English
Published: Wiley 2021-11-01
Series:Physiological Reports
Subjects:
diastolic dysfunction
gene expression
inflammation
myocardial fibrosis
tumor necrosis factor alpha inhibitor
Online Access:https://doi.org/10.14814/phy2.15062

Internet

https://doi.org/10.14814/phy2.15062

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