Synaptic and memory dysfunction induced by tau oligomers is rescued by up-regulation of the nitric oxide cascade

Synaptic and memory dysfunction induced by tau oligomers is rescued by up-regulation of the nitric oxide cascade

Abstract Background Soluble aggregates of oligomeric forms of tau protein (oTau) have been associated with impairment of synaptic plasticity and memory in Alzheimer’s disease. However, the molecular mechanisms underlying the synaptic and memory dysfunction induced by elevation of oTau are still unkn...

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Bibliographic Details
Main Authors: Erica Acquarone, Elentina K. Argyrousi, Manon van den Berg, Walter Gulisano, Mauro Fà, Agnieszka Staniszewski, Elisa Calcagno, Elisa Zuccarello, Luciano D’Adamio, Shi-Xian Deng, Daniela Puzzo, Ottavio Arancio, Jole Fiorito
Format: Article
Language:English
Published: BMC 2019-06-01
Series:Molecular Neurodegeneration
Subjects:
Tau oligomers
Nitric oxide
Soluble guanylyl cyclase
PDE5
Protein kinase G
CREB
Online Access:http://link.springer.com/article/10.1186/s13024-019-0326-4

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http://link.springer.com/article/10.1186/s13024-019-0326-4

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