Aging-dependent changes in rat heart mitochondrial glutaredoxins—Implications for redox regulation

Clinical and animal studies have documented that hearts of the elderly are more susceptible to ischemia/reperfusion damage compared to young adults. Recently we found that aging-dependent increase in susceptibility of cardiomyocytes to apoptosis was attributable to decrease in cytosolic glutaredoxin...

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Bibliographic Details
Main Authors: Xing-Huang Gao, Suparna Qanungo, Harish V. Pai, David W. Starke, Kelly M. Steller, Hisashi Fujioka, Edward J. Lesnefsky, Janos Kerner, Mariana G. Rosca, Charles L. Hoppel, John J. Mieyal
Format: Article
Language:English
Published: Elsevier 2013-01-01
Series:Redox Biology
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231713000797