In Silico Assessment of Class I Antiarrhythmic Drug Effects on <i>Pitx2</i>-Induced Atrial Fibrillation: Insights from Populations of Electrophysiological Models of Human Atrial Cells and Tissues

In Silico Assessment of Class I Antiarrhythmic Drug Effects on <i>Pitx2</i>-Induced Atrial Fibrillation: Insights from Populations of Electrophysiological Models of Human Atrial Cells and Tissues

Electrical remodelling as a result of homeodomain transcription factor 2 (Pitx2)-dependent gene regulation was linked to atrial fibrillation (AF) and AF patients with single nucleotide polymorphisms at chromosome 4q25 responded favorably to class I antiarrhythmic drugs (AADs). The possible reasons b...

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Bibliographic Details
Main Authors: Jieyun Bai, Yijie Zhu, Andy Lo, Meng Gao, Yaosheng Lu, Jichao Zhao, Henggui Zhang
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:International Journal of Molecular Sciences
Subjects:
action potential
atrial fibrillation
in silico model
population of models
class I antiarrhythmic drugs
flecainide
Online Access:https://www.mdpi.com/1422-0067/22/3/1265

Internet

https://www.mdpi.com/1422-0067/22/3/1265

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