Simeprevir restores the anti-Staphylococcus activity of polymyxins

Simeprevir restores the anti-Staphylococcus activity of polymyxins

Abstract Methicillin-resistant Staphylococcus aureus (MRSA) infection poses a severe threat to global public health due to its high mortality. Currently, polymyxins are mainly used for the treatment of Gram-negative bacterial-related infection, while exhibiting limited antibacterial activities again...

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Bibliographic Details
Main Authors: Yuan Wu, Pingyun Wu, Ruolan Wu, Huilong Li, Yao Duan, Chaoni Cai, Zixin Liu, Pengfei She, Di Zhang
Format: Article
Language:English
Published: SpringerOpen 2023-11-01
Series:AMB Express
Subjects:
Staphylococcus aureus
Simeprevir
Polymyxins
Antimicrobial
Drug repurposing
Persister cells
Online Access:https://doi.org/10.1186/s13568-023-01634-8

Internet

https://doi.org/10.1186/s13568-023-01634-8

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