Impact of amiodarone use on metoprolol concentrations, α‐OH‐metoprolol concentrations, metoprolol dosing and heart rate: A cross‐sectional study

Impact of amiodarone use on metoprolol concentrations, α‐OH‐metoprolol concentrations, metoprolol dosing and heart rate: A cross‐sectional study

Abstract Small studies suggest that amiodarone is a weak inhibitor of cytochrome P450 (CYP) 2D6. Inhibition of CYP2D6 leads to increases in concentrations of drugs metabolized by the enzyme, such as metoprolol. Considering that both metoprolol and amiodarone have β‐adrenergic blocking properties and...

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Bibliographic Details
Main Authors: Sabrina Robert, Marc‐Olivier Pilon, Essaïd Oussaïd, Maxime Meloche, Grégoire Leclair, Martin Jutras, Marie‐Josée Gaulin, Ian Mongrain, David Busseuil, Jean‐Claude Tardif, Marie‐Pierre Dubé, Simon deDenus
Format: Article
Language:English
Published: Wiley 2023-10-01
Series:Pharmacology Research & Perspectives
Subjects:
amiodarone
cytochrome P‐450 CYP2D6
drug interactions
metoprolol
pharmacogenetics
pharmacokinetics
Online Access:https://doi.org/10.1002/prp2.1137

Internet

https://doi.org/10.1002/prp2.1137

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