HIV Env conserved element DNA vaccine alters immunodominance in macaques

HIV Env conserved element DNA vaccine alters immunodominance in macaques

Sequence diversity and immunodominance are major obstacles in the design of an effective vaccine against HIV. HIV Env is a highly-glycosylated protein composed of ‘conserved’ and ‘variable’ regions. The latter contains immunodominant epitopes that are frequently targeted by the immune system resulti...

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Bibliographic Details
Main Authors: Xintao Hu, Antonio Valentin, Margherita Rosati, Siriphan Manocheewa, Candido Alicea, Bhabadeb Chowdhury, Jenifer Bear, Kate E. Broderick, Niranjan Y. Sardesai, Sylvie Le Gall, James I. Mullins, George N. Pavlakis, Barbara K. Felber
Format: Article
Language:English
Published: Taylor & Francis Group 2017-12-01
Series:Human Vaccines & Immunotherapeutics
Subjects:
conserved epitopes
cytotoxic t cells
dna vaccine
env
hiv
immunization
prime-boost
rhesus macaque
subdominant epitopes
variable epitopes
Online Access:http://dx.doi.org/10.1080/21645515.2017.1339852

Internet

http://dx.doi.org/10.1080/21645515.2017.1339852

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