A numerical approach for detecting switch-like bistability in mass action chemical reaction networks with conservation laws

Abstract Background Theoretical analysis of signaling pathways can provide a substantial amount of insight into their function. One particular area of research considers signaling pathways capable of assuming two or more stable states given the same amount of signaling ligand. This phenomenon of bis...

Full description

Bibliographic Details
Main Authors: Brandon C Reyes, Irene Otero-Muras, Vladislav A Petyuk
Format: Article
Language:English
Published: BMC 2022-01-01
Series:BMC Bioinformatics
Subjects:
Online Access:https://doi.org/10.1186/s12859-021-04477-x