Whole‐Cell P450 Biocatalysis Using Engineered Escherichia coli with Fine‐Tuned Heme Biosynthesis

Whole‐Cell P450 Biocatalysis Using Engineered Escherichia coli with Fine‐Tuned Heme Biosynthesis

Abstract By exploiting versatile P450 enzymes, whole‐cell biocatalysis can be performed to synthesize valuable compounds in Escherichia coli. However, the insufficient supply of heme limits the whole‐cell P450 biocatalytic activity. Here a strategy for improving intracellular heme biosynthesis to en...

Full description

Bibliographic Details
Main Authors: Baodong Hu, Haibo Yu, Jingwen Zhou, Jianghua Li, Jian Chen, Guocheng Du, Sang Yup Lee, Xinrui Zhao
Format: Article
Language:English
Published: Wiley 2023-02-01
Series:Advanced Science
Subjects:
chemical intermediates
cytochrome P450 enzymes
drugs
Escherichia coli
fine‐tuned heme biosynthesis system
natural products
Online Access:https://doi.org/10.1002/advs.202205580

Internet

https://doi.org/10.1002/advs.202205580

Similar Items