Design and search for prospective diuretics (CA II Inhibitors) among aroylhydrazones of esters quinone oxime using in silico and in vivo methodology

Design and search for prospective diuretics (CA II Inhibitors) among aroylhydrazones of esters quinone oxime using in silico and in vivo methodology

The design and search for new selective inhibitors of CA II with a better pharmacological profile, which would cause minimal electrolyte disturbances in the body, remains an urgent problem of medical chemistry and pharmacology today. It is important that the discovered new classes of inhibitors do n...

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Bibliographic Details
Main Authors: K.V. Sokolova, V.V. Stavytskyi, S.О. Konovalova, O.A. Podpletnya, S.I. Kovalenko, A.P. Avdeenko
Format: Article
Language:English
Published: Dnipro State Medical University 2022-12-01
Series:Medičnì Perspektivi
Subjects:
design
molecular docking
carbonic anhydrase inhibitors
synthesis
aroylhydrazones of esters quinone oximes
diuretic activity
sar analysis
Online Access:http://journals.uran.ua/index.php/2307-0404/article/view/271120

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http://journals.uran.ua/index.php/2307-0404/article/view/271120

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