TrypanocidalActivity of Natural Sesquiterpenoids Involves Mitochondrial Dysfunction, ROS Production and Autophagic Phenotype in <i>Trypanosoma cruzi</i>

TrypanocidalActivity of Natural Sesquiterpenoids Involves Mitochondrial Dysfunction, ROS Production and Autophagic Phenotype in <i>Trypanosoma cruzi</i>

Chagas disease is a neglected tropical disease that is caused by the protozoan <i>Trypanosoma cruzi</i> and represents a serious health problem, especially in Latin America. The clinical treatment of Chagas disease is based on two nitroderivatives that present severe side effects and imp...

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Bibliographic Details
Main Authors: Ana Cristina Souza Bombaça, Daniela Von Dossow, Juliana Magalhães Chaves Barbosa, Cristian Paz, Viviana Burgos, Rubem Figueiredo Sadok Menna-Barreto
Format: Article
Language:English
Published: MDPI AG 2018-10-01
Series:Molecules
Subjects:
<i>Trypanosoma cruzi</i>
chagas disease
chemotherapy
sesquiterpenoids
mitochondria
autophagy
Online Access:https://www.mdpi.com/1420-3049/23/11/2800

Internet

https://www.mdpi.com/1420-3049/23/11/2800

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