Combined anti-S1 and anti-S2 antibodies from hybrid immunity elicit potent cross-variant ADCC against SARS-CoV-2

Combined anti-S1 and anti-S2 antibodies from hybrid immunity elicit potent cross-variant ADCC against SARS-CoV-2

Antibodies capable of neutralizing SARS-CoV-2 are well studied, but Fc receptor–dependent antibody activities that can also significantly impact the course of infection have not been studied in such depth. Since most SARS-CoV-2 vaccines induce only anti-spike antibodies, here we investigated spike-s...

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Bibliographic Details
Main Authors: Michael D. Grant, Kirsten Bentley, Ceri A. Fielding, Keeley M. Hatfield, Danielle P. Ings, Debbie Harnum, Eddie C.Y. Wang, Richard J. Stanton, Kayla A. Holder
Format: Article
Language:English
Published: American Society for Clinical investigation 2023-10-01
Series:JCI Insight
Subjects:
Immunology
Vaccines
Online Access:https://doi.org/10.1172/jci.insight.170681

Internet

https://doi.org/10.1172/jci.insight.170681

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