Increased levels of the synaptic proteins PSD-95, SNAP-25, and neurogranin in the cerebrospinal fluid of patients with Alzheimer’s disease

Increased levels of the synaptic proteins PSD-95, SNAP-25, and neurogranin in the cerebrospinal fluid of patients with Alzheimer’s disease

Abstract Background There is currently a lack of reliable and easily accessible biomarkers predicting cognitive decline in Alzheimer’s disease (AD). Synaptic dysfunction and loss occur early in AD and synaptic loss measured in the brain tissue and by PET are closely linked to cognitive decline, rend...

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Bibliographic Details
Main Authors: Pia Kivisäkk, Becky C. Carlyle, Thadryan Sweeney, James P. Quinn, Christopher E. Ramirez, Bianca A. Trombetta, Muriel Mendes, Mary Brock, Carrie Rubel, Julie Czerkowicz, Danielle Graham, Steven E. Arnold
Format: Article
Language:English
Published: BMC 2022-04-01
Series:Alzheimer’s Research & Therapy
Subjects:
Alzheimer’s disease
Biomarkers
Cerebrospinal fluid
Synaptic markers
PSD-95
SNAP-25
Online Access:https://doi.org/10.1186/s13195-022-01002-x

Internet

https://doi.org/10.1186/s13195-022-01002-x

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