Genotype-guided versus traditional clinical dosing of warfarin in patients of Asian ancestry: a randomized controlled trial

Genotype-guided versus traditional clinical dosing of warfarin in patients of Asian ancestry: a randomized controlled trial

Abstract Background Genotype-guided warfarin dosing has been shown in some randomized trials to improve anticoagulation outcomes in individuals of European ancestry, yet its utility in Asian patients remains unresolved. Methods An open-label, non-inferiority, 1:1 randomized trial was conducted at th...

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Bibliographic Details
Main Authors: Nicholas L. Syn, Andrea Li-Ann Wong, Soo-Chin Lee, Hock-Luen Teoh, James Wei Luen Yip, Raymond CS Seet, Wee Tiong Yeo, William Kristanto, Ping-Chong Bee, LM Poon, Patrick Marban, Tuck Seng Wu, Michael D. Winther, Liam R. Brunham, Richie Soong, Bee-Choo Tai, Boon-Cher Goh
Format: Article
Language:English
Published: BMC 2018-07-01
Series:BMC Medicine
Subjects:
Pharmacogenetics
Pharmacogenomics
Precision medicine
CYP2C9
Cytochrome P450
VKORC1
Online Access:http://link.springer.com/article/10.1186/s12916-018-1093-8

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http://link.springer.com/article/10.1186/s12916-018-1093-8

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