Celastrol gel ameliorates imiquimod-induced psoriasis-like dermatitis in mice by targeting Langerhans cells

Background: Psoriasis is an autoimmune disease mediated by T cells. However, treatment remains a clinical challenge because of its frequent recurrence. Celastrol (Cel), the main active ingredient in Tripterygium wilfordii Hook F, is efficacious in treating autoimmune diseases such as psoriasis. Obje...

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Bibliographic Details
Main Authors: Liu Liu, Xi Chen, Yi Lu, Xiao-Ying Sun, Kan Ze, Ya-Qiong Zhou, Wei Li, Xin Li, Hong-Jin Li, Bin Li
Format: Article
Language:English
Published: Elsevier 2022-03-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332222000324