A protospacer adjacent motif‐free, multiplexed, and quantitative nucleic acid detection platform with barcode‐based Cas12a activity

A protospacer adjacent motif‐free, multiplexed, and quantitative nucleic acid detection platform with barcode‐based Cas12a activity

Abstract Clustered regularly interspaced short palindromic repeat (CRISPR)‐based biosensors have been developed to facilitate the rapid and sensitive detection of nucleic acids. However, most approaches using CRISPR‐based detection have disadvantages associated with the limitations of CRISPR RNA (cr...

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Bibliographic Details
Main Authors: Miaojin Zhou, Chunhua Zhang, Miaomiao Chen, Zhiqing Hu, Menglin Li, Zhuo Li, Lingqian Wu, Desheng Liang
Format: Article
Language:English
Published: Wiley 2023-08-01
Series:MedComm
Subjects:
barcode‐based Cas12a
copy number variation
simultaneous detection of multiple targets
spinal muscular atrophy
universal PAM and crRNA
Online Access:https://doi.org/10.1002/mco2.310

Internet

https://doi.org/10.1002/mco2.310

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