An adaptive, negative feedback circuit in a biohybrid device reprograms dynamic networks of systemic inflammation in vivo

An adaptive, negative feedback circuit in a biohybrid device reprograms dynamic networks of systemic inflammation in vivo

Introduction: Systemic acute inflammation accompanies and underlies the pathobiology of sepsis but is also central to tissue healing. We demonstrated previously the in vivo feasibility of modulating the key inflammatory mediator tumor necrosis factor-alpha (TNF-α) through the constitutive production...

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Bibliographic Details
Main Authors: Rami A. Namas, Maxim Mikheev, Jinling Yin, Derek Barclay, Bahiyyah Jefferson, Qi Mi, Timothy R. Billiar, Ruben Zamora, Jorg Gerlach, Yoram Vodovotz
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Systems Biology
Subjects:
endotoxemia
sepsis
lipopolysaccharide
tumor necrosis factor
sTNFR
HepG2 cells
Online Access:https://www.frontiersin.org/articles/10.3389/fsysb.2022.926618/full

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https://www.frontiersin.org/articles/10.3389/fsysb.2022.926618/full

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