4-Chloroisocoumarins as Chlamydial Protease Inhibitors and Anti-Chlamydial Agents

4-Chloroisocoumarins as Chlamydial Protease Inhibitors and Anti-Chlamydial Agents

4-Chloroisocoumarin compounds have broad inhibitory properties against serine proteases. Here, we show that selected 3-alkoxy-4-chloroisocoumarins preferentially inhibit the activity of the conserved serine protease High-temperature requirement A of <i>Chlamydia trachomatis</i>. The synt...

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Bibliographic Details
Main Authors: Matthew J. A. Phillips, Wilhelmina M. Huston, Andrew M. McDonagh, Tristan Rawling
Format: Article
Language:English
Published: MDPI AG 2024-03-01
Series:Molecules
Subjects:
anti-chlamydial
protease inhibitor
isocoumarin
Online Access:https://www.mdpi.com/1420-3049/29/7/1519

Internet

https://www.mdpi.com/1420-3049/29/7/1519

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