A simple route to a novel acid-sensitive 20(S)-O-linked camptothecin norcantharidin acid ester derivative

A facile synthetic method was developed for a novel acid-sensitive camptothecin norcantharidin acid ester derivative I. The total yield can reach 71%. This method provides several advantages, including high yield and simple working procedure for the synthesis of analogues. The new synthetic compound...

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Bibliographic Details
Main Authors: Changkuo Zhao, Xianheng Wang, Fuhong Yang, Lei Gao, Yuhe Wang
Format: Article
Language:English
Published: The Royal Society 2018-01-01
Series:Royal Society Open Science
Subjects:
Online Access:https://royalsocietypublishing.org/doi/pdf/10.1098/rsos.170842