A simple route to a novel acid-sensitive 20(S)-O-linked camptothecin norcantharidin acid ester derivative
A facile synthetic method was developed for a novel acid-sensitive camptothecin norcantharidin acid ester derivative I. The total yield can reach 71%. This method provides several advantages, including high yield and simple working procedure for the synthesis of analogues. The new synthetic compound...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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The Royal Society
2018-01-01
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| Series: | Royal Society Open Science |
| Subjects: | |
| Online Access: | https://royalsocietypublishing.org/doi/pdf/10.1098/rsos.170842 |
| _version_ | 1818262470084526080 |
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| author | Changkuo Zhao Xianheng Wang Fuhong Yang Lei Gao Yuhe Wang |
| author_facet | Changkuo Zhao Xianheng Wang Fuhong Yang Lei Gao Yuhe Wang |
| author_sort | Changkuo Zhao |
| collection | DOAJ |
| description | A facile synthetic method was developed for a novel acid-sensitive camptothecin norcantharidin acid ester derivative I. The total yield can reach 71%. This method provides several advantages, including high yield and simple working procedure for the synthesis of analogues. The new synthetic compound I has been shown to exhibit better solubility and similar activity against tumour cell lines. |
| first_indexed | 2024-12-12T19:03:38Z |
| format | Article |
| id | doaj.art-087f15514f1249cd835f4d596132f9d6 |
| institution | Directory Open Access Journal |
| issn | 2054-5703 |
| language | English |
| last_indexed | 2024-12-12T19:03:38Z |
| publishDate | 2018-01-01 |
| publisher | The Royal Society |
| record_format | Article |
| series | Royal Society Open Science |
| spelling | doaj.art-087f15514f1249cd835f4d596132f9d62022-12-22T00:15:00ZengThe Royal SocietyRoyal Society Open Science2054-57032018-01-015210.1098/rsos.170842170842A simple route to a novel acid-sensitive 20(S)-O-linked camptothecin norcantharidin acid ester derivativeChangkuo ZhaoXianheng WangFuhong YangLei GaoYuhe WangA facile synthetic method was developed for a novel acid-sensitive camptothecin norcantharidin acid ester derivative I. The total yield can reach 71%. This method provides several advantages, including high yield and simple working procedure for the synthesis of analogues. The new synthetic compound I has been shown to exhibit better solubility and similar activity against tumour cell lines.https://royalsocietypublishing.org/doi/pdf/10.1098/rsos.170842camptothecinnorcantharidinsynthesiswater solubilitytumour |
| spellingShingle | Changkuo Zhao Xianheng Wang Fuhong Yang Lei Gao Yuhe Wang A simple route to a novel acid-sensitive 20(S)-O-linked camptothecin norcantharidin acid ester derivative Royal Society Open Science camptothecin norcantharidin synthesis water solubility tumour |
| title | A simple route to a novel acid-sensitive 20(S)-O-linked camptothecin norcantharidin acid ester derivative |
| title_full | A simple route to a novel acid-sensitive 20(S)-O-linked camptothecin norcantharidin acid ester derivative |
| title_fullStr | A simple route to a novel acid-sensitive 20(S)-O-linked camptothecin norcantharidin acid ester derivative |
| title_full_unstemmed | A simple route to a novel acid-sensitive 20(S)-O-linked camptothecin norcantharidin acid ester derivative |
| title_short | A simple route to a novel acid-sensitive 20(S)-O-linked camptothecin norcantharidin acid ester derivative |
| title_sort | simple route to a novel acid sensitive 20 s o linked camptothecin norcantharidin acid ester derivative |
| topic | camptothecin norcantharidin synthesis water solubility tumour |
| url | https://royalsocietypublishing.org/doi/pdf/10.1098/rsos.170842 |
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