Knockdown of hepatic mitochondrial calcium uniporter mitigates MASH and fibrosis in mice

Knockdown of hepatic mitochondrial calcium uniporter mitigates MASH and fibrosis in mice

Abstract Background Mitochondrial calcium uniporter (MCU) plays pleiotropic roles in cellular physiology and pathology that contributes to a variety of diseases, but the role and potential mechanism of MCU in the pathogenesis of metabolic dysfunction-associated steatohepatitis (MASH) remain poorly u...

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Bibliographic Details
Main Authors: Shuyu Li, Fangyuan Chen, Min Liu, Yajun Zhang, Jingjing Xu, Xi Li, Zhiyin Shang, Shaoping Huang, Shu Song, Chuantao Tu
Format: Article
Language:English
Published: BMC 2024-11-01
Series:Cell & Bioscience
Subjects:
MCU
Steatohepatitis
Liver fibrosis
Mitochondrial dysfunction
Oxidative stress
Online Access:https://doi.org/10.1186/s13578-024-01315-4

Internet

https://doi.org/10.1186/s13578-024-01315-4

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