The FAM104 proteins VCF1/2 promote the nuclear localization of p97/VCP

The FAM104 proteins VCF1/2 promote the nuclear localization of p97/VCP

The ATPase p97 (also known as VCP, Cdc48) has crucial functions in a variety of important cellular processes such as protein quality control, organellar homeostasis, and DNA damage repair, and its de-regulation is linked to neuromuscular diseases and cancer. p97 is tightly controlled by numerous reg...

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Bibliographic Details
Main Authors: Maria Körner, Susanne R Meyer, Gabriella Marincola, Maximilian J Kern, Clemens Grimm, Christina Schuelein-Voelk, Utz Fischer, Kay Hofmann, Alexander Buchberger
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2023-09-01
Series:eLife
Subjects:
p97 VCP Cdc48
ubiquitin proteasome system
nuclear import
DNA damage repair
FAM104A FLJ14775
FAM104B FLJ20434 CXorf44
Online Access:https://elifesciences.org/articles/92409

Internet

https://elifesciences.org/articles/92409

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