Histone acetyltransferase NAA40 modulates acetyl-CoA levels and lipid synthesis

Histone acetyltransferase NAA40 modulates acetyl-CoA levels and lipid synthesis

Abstract Background Epigenetic regulation relies on the activity of enzymes that use sentinel metabolites as cofactors to modify DNA or histone proteins. Thus, fluctuations in cellular metabolite levels have been reported to affect chromatin modifications. However, whether epigenetic modifiers also...

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Bibliographic Details
Main Authors: Evelina Charidemou, Maria A. Tsiarli, Andria Theophanous, Vural Yilmaz, Chrysoula Pitsouli, Katerina Strati, Julian L. Griffin, Antonis Kirmizis
Format: Article
Language:English
Published: BMC 2022-01-01
Series:BMC Biology
Subjects:
Histone acetyltransferases
NAA40
acetyl-CoA
Lipid metabolism
Epigenetics
Drosophila melanogaster
Online Access:https://doi.org/10.1186/s12915-021-01225-8

Internet

https://doi.org/10.1186/s12915-021-01225-8

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