Plasmacytoid dendritic cells accumulate and secrete interferon alpha in lymph nodes of HIV-1 patients.

Plasmacytoid dendritic cells accumulate and secrete interferon alpha in lymph nodes of HIV-1 patients.

Circulating plasmacytoid dendritic cells (pDC) decline during HIV-1 infection, but at the same time they express markedly higher levels of interferon alpha (IFNalpha), which is associated with HIV-1 disease progression. Here we show an accumulation of pDC in lymph nodes (LN) of treatment-naïve HIV-1...

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Bibliographic Details
Main Authors: Clara Lehmann, Mark Lafferty, Alfredo Garzino-Demo, Norma Jung, Pia Hartmann, Gerd Fätkenheuer, Jeffrey S Wolf, Jan van Lunzen, Fabio Romerio
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-06-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2885422?pdf=render

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http://europepmc.org/articles/PMC2885422?pdf=render

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