Trimidox-Induced Apoptosis Is Mediated Through Induction of p53 in NALM-6 Cells

We examined the effect of trimidox-induced apoptosis involvement of p53 in the NALM-6 cell line of acute lymphoblastic leukemia. Trimidox has been shown to increase the induction of p53. Phosphorylation of p53 protein at Ser-15 and Ser-20 residues was activated earlier than the obvious increase in p...

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Bibliographic Details
Main Authors: Syu-ichi Kanno, Takaharu Ohtake, Yuu Osanai, Kaori Kurauchi, Mayuko Ujibe, Koji Uwai, Mituhiro Takeshita, Susumu Satoh, Masaaki Ishikawa
Format: Article
Language:English
Published: Elsevier 2008-01-01
Series:Journal of Pharmacological Sciences
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861319340836